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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (December 2008) edit 1-acylglycerol-3-phosphate O-acyltransferase 3 Identifiers Symbols AGPAT3; LPAAT-GAMMA1; MGC4604 External IDs MGI: 1336186 HomoloGene: 10591 GeneCards: AGPAT3 Gene Gene Ontology Molecular function • 1-acylglycerol-3-phosphate O-acyltransferase activity • acyltransferase activity • transferase activity Cellular component • cellular_component • membrane • integral to membrane Biological process • metabolic process • phospholipid biosynthetic process Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 56894 28169 Ensembl ENSG00000160216 ENSMUSG00000001211 UniProt Q9NRZ7 Q3TXT9 RefSeq (mRNA) NM_001037553 NM_053014 RefSeq (protein) NP_001032642 NP_443747 Location (UCSC) Chr 21: 44.11 - 44.23 Mb Chr 10: 77.67 - 77.75 Mb PubMed search [1] [2] 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an enzyme that in humans is encoded by the AGPAT3 gene.[1] The protein encoded by this gene is an acyltransferase that converts lysophosphatidic acid into phosphatidic acid, which is the second step in the de novo phospholipid biosynthetic pathway. The encoded protein may be an integral membrane protein. Two transcript variants encoding the same protein have been found for this gene.[1] References ^ a b "Entrez Gene: AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56894.  Further reading Leung DW (2001). "The structure and functions of human lysophosphatidic acid acyltransferases.". Front. Biosci. 6: D944–53. doi:10.2741/Leung. PMID 11487472.  Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium.". Mol. Vis. 8: 185–95. PMID 12107412.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Lu B, Jiang YJ, Zhou Y, et al. (2005). "Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARalpha in murine heart.". Biochem. J. 385 (Pt 2): 469–77. doi:10.1042/BJ20041348. PMID 15367102.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Agarwal AK, Barnes RI, Garg A (2006). "Functional characterization of human 1-acylglycerol-3-phosphate acyltransferase isoform 8: cloning, tissue distribution, gene structure, and enzymatic activity.". Arch. Biochem. Biophys. 449 (1-2): 64–76. doi:10.1016/j.abb.2006.03.014. PMID 16620771.  Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins.". BMC Genomics 7: 155. doi:10.1186/1471-2164-7-155. PMID 16780588.  This article on a gene on chromosome 21 is a stub. You can help Wikipedia by expanding it. v • d • e