Your IP: 38.107.179.224 United States Near: United States

Lookup IP Information

1 2 3 4 5 6 7 8 Next

Below is the list of all allocated IP address in 8.169.0.0 - 8.169.255.255 network range, sorted by latency.

edit TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) PDB rendering based on 1fvr. Available structures PDB 1fvr, 2gy5, 2gy7, 2oo8, 2osc, 2p4i Identifiers Symbols TEK; CD202B; TIE-2; TIE2; VMCM; VMCM1 External IDs OMIM: 600221 MGI: 98664 HomoloGene: 397 GeneCards: TEK Gene Gene Ontology Molecular function • nucleotide binding • transmembrane receptor protein tyrosine kinase activity • receptor activity • ATP binding • kinase activity • transferase activity Cellular component • integral to plasma membrane • membrane Biological process • protein amino acid phosphorylation • signal transduction • transmembrane receptor protein tyrosine kinase signaling pathway • cell-cell signaling Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 7010 21687 Ensembl ENSG00000120156 ENSMUSG00000006386 UniProt Q02763 Q02858 RefSeq (mRNA) NM_000459 NM_013690 RefSeq (protein) NP_000450 NP_038718 Location (UCSC) Chr 9: 27.1 - 27.22 Mb Chr 4: 94.23 - 94.37 Mb PubMed search [1] [2] Angiopoietin-1 receptor is a protein that in humans is encoded by the TEK gene.[1][2] TEK has also recently been designated CD202B (cluster of differentiation 202B). The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.[3] Contents 1 Interactions 2 References 3 External links 4 Further reading // Interactions TEK tyrosine kinase has been shown to interact with DOK2,[4][5] Angiopoietin 1[6][7][8][9] and ANGPT2.[6][8][9] References ^ Partanen J, Armstrong E, Makela TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Mol Cell Biol 12 (4): 1698–707. PMID 1312667.  ^ Boon LM, Mulliken JB, Vikkula M, Watkins H, Seidman J, Olsen BR, Warman ML (February 1995). "Assignment of a locus for dominantly inherited venous malformations to chromosome 9p". Hum Mol Genet 3 (9): 1583–7. doi:10.1093/hmg/3.9.1583. PMID 7833915.  ^ "Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7010.  ^ Jones, N; Dumont D J (September 1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R". Oncogene (ENGLAND) 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. ISSN 0950-9232. PMID 9764820.  ^ Master, Z; Jones N, Tran J, Jones J, Kerbel R S, Dumont D J (November 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO J. (England) 20 (21): 5919–28. doi:10.1093/emboj/20.21.5919. ISSN 0261-4189. PMID 11689432.  ^ a b Fiedler, Ulrike; Krissl Tanja, Koidl Stefanie, Weiss Cornelia, Koblizek Thomas, Deutsch Urban, Martiny-Baron Georg, Marmé Dieter, Augustin Hellmut G (January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. (United States) 278 (3): 1721–7. doi:10.1074/jbc.M208550200. ISSN 0021-9258. PMID 12427764.  ^ Davis, S; Aldrich T H, Jones P F, Acheson A, Compton D L, Jain V, Ryan T E, Bruno J, Radziejewski C, Maisonpierre P C, Yancopoulos G D (December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell (UNITED STATES) 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. ISSN 0092-8674. PMID 8980223.  ^ a b Sato, A; Iwama A, Takakura N, Nishio H, Yancopoulos G D, Suda T (August 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. (ENGLAND) 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. ISSN 0953-8178. PMID 9723709.  ^ a b Maisonpierre, P C; Suri C, Jones P F, Bartunkova S, Wiegand S J, Radziejewski C, Compton D, McClain J, Aldrich T H, Papadopoulos N, Daly T J, Davis S, Sato T N, Yancopoulos G D (July 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science (UNITED STATES) 277 (5322): 55–60. doi:10.1126/science.277.5322.55. ISSN 0036-8075. PMID 9204896.  External links GeneReview/NIH/UW entry on Multiple Cutaneous and Mucosal Venous Malformations Further reading Huang L, Turck CW, Rao P, Peters KG (1995). "GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase.". Oncogene 11 (10): 2097–103. PMID 7478529.  Deans JP, Kalt L, Ledbetter JA, et al. (1995). "Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20.". J. Biol. Chem. 270 (38): 22632–8. doi:10.1074/jbc.270.38.22632. PMID 7545683.  Gallione CJ, Pasyk KA, Boon LM, et al. (1995). "A gene for familial venous malformations maps to chromosome 9p in a second large kindred.". J. Med. Genet. 32 (3): 197–9. doi:10.1136/jmg.32.3.197. PMID 7783168.  Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.  Dumont DJ, Anderson L, Breitman ML, Duncan AM (1995). "Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21.". Genomics 23 (2): 512–3. doi:10.1006/geno.1994.1536. PMID 7835909.  Ziegler SF, Bird TA, Schneringer JA, et al. (1993). "Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta.". Oncogene 8 (3): 663–70. PMID 8382358.  Davis S, Aldrich TH, Jones PF, et al. (1997). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning.". Cell 87 (7): 1161–9. doi:10.1016/S0092-8674(00)81812-7. PMID 8980223.  Suri C, Jones PF, Patan S, et al. (1997). "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis.". Cell 87 (7): 1171–80. doi:10.1016/S0092-8674(00)81813-9. PMID 8980224.  Vikkula M, Boon LM, Carraway KL, et al. (1997). "Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2.". Cell 87 (7): 1181–90. doi:10.1016/S0092-8674(00)81814-0. PMID 8980225.  Witzenbichler B, Maisonpierre PC, Jones P, et al. (1998). "Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2.". J. Biol. Chem. 273 (29): 18514–21. doi:10.1074/jbc.273.29.18514. PMID 9660821.  Asahara T, Chen D, Takahashi T, et al. (1998). "Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.". Circ. Res. 83 (3): 233–40. PMID 9710115.  Sato A, Iwama A, Takakura N, et al. (1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells.". Int. Immunol. 10 (8): 1217–27. doi:10.1093/intimm/10.8.1217. PMID 9723709.  Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R.". Oncogene 17 (9): 1097–108. doi:10.1038/sj.onc.1202115. PMID 9764820.  De Sepulveda P, Okkenhaug K, Rose JL, et al. (1999). "Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation.". EMBO J. 18 (4): 904–15. doi:10.1093/emboj/18.4.904. PMID 10022833.  Valenzuela DM, Griffiths JA, Rojas J, et al. (1999). "Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.". Proc. Natl. Acad. Sci. U.S.A. 96 (5): 1904–9. doi:10.1073/pnas.96.5.1904. PMID 10051567.  Calvert JT, Riney TJ, Kontos CD, et al. (1999). "Allelic and locus heterogeneity in inherited venous malformations.". Hum. Mol. Genet. 8 (7): 1279–89. doi:10.1093/hmg/8.7.1279. PMID 10369874.  Jones N, Master Z, Jones J, et al. (1999). "Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration.". J. Biol. Chem. 274 (43): 30896–905. doi:10.1074/jbc.274.43.30896. PMID 10521483.  Fachinger G, Deutsch U, Risau W (1999). "Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2.". Oncogene 18 (43): 5948–53. doi:10.1038/sj.onc.1202992. PMID 10557082.  v • d • e PDB Gallery 1fvr: TIE2 KINASE DOMAIN   2gy5: Tie2 Ligand-Binding Domain Crystal Structure   2gy7: Angiopoietin-2/Tie2 Complex Crystal Structure   2oo8: Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors   2osc: Synthesis, Structural Analysis, and SAR Studies of Triazine Derivatives as Potent, Selective Tie-2 Inhibitors   2p4i: Evolution of a highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor   This article incorporates text from the United States National Library of Medicine, which is in the public domain. v • d • e Protein kinases: tyrosine kinases (EC 2.7.10)   Receptor tyrosine kinases (EC 2.7.10.1) EGF receptor family EGFR · ERBB2 · ERBB3 · ERBB4 Insulin receptor family IGF1R · INSR · INSRR PDGF receptor family CSF1R · FLT3 · KIT · PDGFR (PDGFRA, PDGFRB) FGF receptor family FGFR1 · FGFR2 · FGFR3 · FGFR4 VEGF receptors family VEGFR1 · VEGFR2 · VEGFR3 · VEGFR4 HGF receptor family MET · RON Trk receptor family NTRK1 · NTRK2 · NTRK3 EPH receptor family EPHA1 · EPHA2 · EPHA3 · EPHA4 · EPHA5 · EPHA6 · EPHA7 · EPHA8 · EPHB1 · EPHB2 · EPHB3 · EPHB4 · EPHB5 · EPHB6 · EPHX LTK receptor family LTK · ALK TIE receptor family TIE · TEK ROR receptor family ROR1 · ROR2 DDR receptor family DDR1 · DDR2 PTK7 receptor family PTK7 RYK receptor family RYK MuSK receptor family MUSK ROS receptor family ROS1 AATYK receptor family AATYK · AATYK2 · AATYK3 AXL receptor family AXL · MER · TYRO3 RET receptor family RET uncatagorised STYK1   Non-receptor tyrosine kinases (EC 2.7.10.2) ABL family ABL1 · ARG ACK family ACK1 · TNK1 CSK family CSK · MATK FAK family FAK · PYK2 FES family FES · FER FRK family FRK · BRK · SRMS JAK family JAK1 · JAK2 · JAK3 · TYK2 SRC-A family SRC · FGR · FYN · YES1 SRC-B family BLK · HCK · LCK · LYN TEC family TEC · BMX · BTK · ITK · TXK SYK family SYK · ZAP70 v • d • e Proteins: clusters of differentiation (see also list of human clusters of differentiation) 1-50 CD1 (a-c, 1A, 1D, 1E) · CD2 · CD3 (γ, δ, ε) · CD4 · CD5 · CD6 · CD7 · CD8 (a) · CD9 · CD10 · CD11 (a, b, c) · CD13 · CD14 · CD15 · CD16 (A, B) · CD18 · CD19 · CD20 · CD21 · CD22 · CD23 · CD24 · CD25 · CD26 · CD27 · CD28 · CD29 · CD30 · CD31 · CD32 (A, B) · CD33 · CD34 · CD35 · CD36 · CD37 · CD38 · CD39 · CD40 · CD41 · CD42 (a, b, c, d) · CD43 · CD44 · CD45 · CD46 · CD47 · CD48 · CD49 (a, b, c, d, e, f) · CD50 51-100 CD51 · CD52 · CD53 · CD54 · CD55 · CD56 · CD57 · CD58 · CD59 · CD61 · CD62 (E, L, P) · CD63 · CD64 (A, B, C) · CD66 (a, b, c, d, e, f) · CD68 · CD69 · CD70 · CD71 · CD72 · CD73 · CD74 · CD78 · CD79 (a, b) · CD80 · CD81 · CD82 · CD83 · CD84 · CD85 (a, d, e, h, j, k) · CD86 · CD87 · CD88 · CD89 · CD90 · CD91- CD92 · CD93 · CD94 · CD95 · CD96 · CD97 · CD98 · CD99 · CD100 101-150 CD101 · CD102 · CD103 · CD104 · CD105 · CD106 · CD107 (a, b) · CD108 · CD109 · CD110 · CD111 · CD112 · CD113 · CD114 · CD115 · CD116 · CD117 · CD118 · CD119 · CD120 (a, b) · CD121 (a, b) · CD122 · CD123 · CD124 · CD125 · CD126 · CD127 · CD129 · CD130 · CD131 · CD132 · CD133 · CD134 · CD135 · CD136 · CD137 · CD138 · CD140b · CD141 · CD142 · CD143 · CD144 · CD146 · CD147 · CD148 · CD150 151-200 CD151 · CD152 · CD153 · CD154 · CD155 · CD156 (a, b, c) · CD157 · CD158 (a, d, e, i, k) · CD159 (a, c) · CD160 · CD161 · CD162 · CD163 · CD164 · CD166 · CD167 (a, b) · CD168 · CD169 · CD170 · CD171 · CD172 (a, b, g) · CD174 · CD177 · CD178 · CD179 (a, b) · CD181 · CD182 · CD183 · CD184 · CD185 · CD186 · CD191 · CD192 · CD193 · CD194 · CD195 · CD196 · CD197 · CDw198 · CDw199 · CD200 201-250 CD201 · CD202b · CD204 · CD205 · CD206 · CD207 · CD208 · CD209 · CDw210 (a, b) · CD212 · CD213a (1, 2) · CD217 · CD218 (a, b) · CD220 · CD221 · CD222 · CD223 · CD224 · CD225 · CD226 · CD227 · CD228 · CD229 · CD230 · CD233 · CD234 · CD235 (a, b) · CD236 · CD238 · CD239 · CD240CE · CD241 · CD243 · CD244 · CD246 · CD247- CD248 · CD249 251-300 CD252 · CD253 · CD254 · CD256 · CD257 · CD258 · CD261 · CD262 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD271 · CD272 · CD273 · CD274 · CD275 · CD276 · CD278 · CD279 · CD280 · CD281 · CD282 · CD283 · CD284 · CD286 · CD288 · CD289 · CD290 · CD292 · CDw293 · CD294 · CD295 · CD297 · CD298 · CD299 301-350 CD300A · CD301 · CD302 · CD303 · CD304 · CD305 · CD306 · CD307 · CD309 · CD312 · CD314 · CD315 · CD316 · CD317 · CD318 · CD320 · CD321 · CD322 · CD324 · CD325 · CD326 · CD328 · CD329 · CD331 · CD332 · CD333 · CD334 · CD335 · CD336 · CD337 · CD338 · CD339 · CD340 · CD344 · CD349 · CD350 This membrane protein-related article is a stub. You can help Wikipedia by expanding it. v • d • e