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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) edit Soc-2 suppressor of clear homolog (C. elegans) Identifiers Symbols SHOC2; KIAA0862; SIAA0862; SOC-2; SOC2; SUR-8; SUR8 External IDs OMIM: 602775 MGI: 1927197 HomoloGene: 7219 GeneCards: SHOC2 Gene Gene Ontology Molecular function • molecular_function • protein binding Cellular component • cytoplasm Biological process • Ras protein signal transduction • fibroblast growth factor receptor signaling pathway Sources: Amigo / QuickGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 8036 56392 Ensembl ENSG00000108061 ENSMUSG00000024976 UniProt Q9UQ13 Q8R378 RefSeq (mRNA) NM_007373 NM_019658 RefSeq (protein) NP_031399 NP_062632 Location (UCSC) Chr 10: 112.67 - 112.76 Mb Chr 19: 54 - 54.09 Mb PubMed search [1] [2] Leucine-rich repeat protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene.[1][2][3][4] Interactions SHOC2 has been shown to interact with C-Raf[3] and HRAS.[3] References ^ Selfors LM, Schutzman JL, Borland CZ, Stern MJ (Jul 1998). "soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling". Proc Natl Acad Sci U S A 95 (12): 6903–8. doi:10.1073/pnas.95.12.6903. PMC 22679. PMID 9618511. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22679.  ^ Sieburth DS, Sun Q, Han M (Aug 1998). "SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans". Cell 94 (1): 119–30. doi:10.1016/S0092-8674(00)81227-1. PMID 9674433.  ^ a b c Li W, Han M, Guan KL (May 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev 14 (8): 895–900. PMC 316541. PMID 10783161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316541.  ^ "Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8036.  Further reading Dai P, Xiong WC, Mei L (2006). "Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex.". J. Biol. Chem. 281 (2): 927–33. doi:10.1074/jbc.M507360200. PMID 16301319.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.  Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.  This article on a gene on chromosome 10 is a stub. You can help Wikipedia by expanding it.v · d · e