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Small nucleolar RNA MBII-202 Type: Gene; snRNA; snoRNA; CD-box; 2° structure: Predicted; PFOLD; Moxon SJ Seed alignment: Moxon SJ Avg length: 80.60 nucleotides Avg identity: 66.00% Small nucleolar RNA MBII-202 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifiying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA MBII-202 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs[1][2]. snoRNA MBII-202 was originally cloned from mouse brain tissues[3]. References ^ Galardi, S; Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Mol Cell Biol 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMID 12215523.  ^ Kiss, T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell 109 (2): 145–148. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400.  ^ Huttenhofer A, Kiefmann M, Meier-Ewert S, et al. (2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". EMBO J. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMID 11387227.  External links Rfam page for Small nucleolar RNA MBII-202 This molecular or cell biology article is a stub. You can help Wikipedia by expanding it. v • d • e