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This article is an orphan, as few or no other articles link to it. Please introduce links to this page from related articles; suggestions may be available. (February 2009) edit Defensin, beta 126 Identifiers Symbols DEFB126; C20orf8; DEFB-26; DEFB26; ESP13.2; bA530N10.1; hBD-26 External IDs HomoloGene: 49954 GeneCards: DEFB126 Gene Gene Ontology Molecular function • protease inhibitor activity Cellular component • extracellular region Biological process • proteolysis • defense response to bacterium Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 81623 n/a Ensembl ENSG00000125788 n/a UniProt Q9BYW3 n/a RefSeq (mRNA) NM_030931 n/a RefSeq (protein) NP_112193 n/a Location (UCSC) Chr 20: 0.07 - 0.07 Mb n/a PubMed search [1] n/a Beta-defensin 126 is a protein that in humans is encoded by the DEFB126 gene.[1][2] Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13. The encoded protein is highly similar to an epididymal-specific secretory protein (ESP13.2) from cynomolgus monkey.[2] References ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMID 11854508.  ^ a b "Entrez Gene: DEFB126 defensin, beta 126". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=81623.  Further reading Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis.". Genomics 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.  Perry AC, Jones R, Moisyadi S, et al. (1999). "The novel epididymal secretory protein ESP13.2 in Macaca fascicularis.". Biol. Reprod. 61 (4): 965–72. doi:10.1095/biolreprod61.4.965. PMID 10491631.  Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.  Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.  This article on a gene on chromosome 20 is a stub. You can help Wikipedia by expanding it. v • d • e