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edit ATP-binding cassette, sub-family B (MDR/TAP), member 9 Identifiers Symbols ABCB9; EST122234; KIAA1520; TAPL External IDs OMIM: 605453 MGI: 1861729 HomoloGene: 10491 GeneCards: ABCB9 Gene Gene Ontology Molecular function • nucleotide binding • transporter activity • ATP binding • oligopeptide transporter activity • ATPase activity • ATPase activity, coupled to transmembrane movement of substances Cellular component • lysosome • endoplasmic reticulum • membrane • integral to membrane • ATP-binding cassette (ABC) transporter complex Biological process • transport • oligopeptide transport • spermatogenesis • protein transport Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 23457 56325 Ensembl ENSG00000150967 ENSMUSG00000029408 UniProt Q9NP78 Q9JJ59 RefSeq (mRNA) NM_019624 NM_019875 RefSeq (protein) NP_062570 NP_063928 Location (UCSC) Chr 12: 121.98 - 122.03 Mb Chr 5: 124.32 - 124.36 Mb PubMed search [1] [2] ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.[1][2] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.[2] Contents 1 See also 2 References 3 Further reading 4 External links // See also ATP-binding cassette transporter References ^ Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database.". Hum Mol Genet 5 (10): 1649–55. doi:10.1093/hmg/5.10.1649. PMID 8894702.  ^ a b "Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23457.  Further reading Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.  Zhang F, Zhang W, Liu L, et al. (2000). "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes.". J. Biol. Chem. 275 (30): 23287–94. doi:10.1074/jbc.M001819200. PMID 10748049.  Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.  Kobayashi A, Kasano M, Maeda T, et al. (2000). "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2.". J. Biochem. 128 (4): 711–8. PMID 11011155.  Saito S, Iida A, Sekine A, et al. (2002). "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population.". J. Hum. Genet. 47 (1): 38–50. doi:10.1007/s10038-002-8653-6. PMID 11829140.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Kobayashi A, Hori S, Suita N, Maeda M (2003). "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity.". Biochem. Biophys. Res. Commun. 309 (4): 815–22. doi:10.1016/j.bbrc.2003.08.081. PMID 13679046.  Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.  Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain.". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID 15491607.  Wolters JC, Abele R, Tampé R (2005). "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9).". J. Biol. Chem. 280 (25): 23631–6. doi:10.1074/jbc.M503231200. PMID 15863492.  Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  Ohashi-Kobayashi A, Ohashi K, Du WB, et al. (2006). "Examination of drug resistance activity of human TAP-like (ABCB9) expressed in yeast.". Biochem. Biophys. Res. Commun. 343 (2): 597–601. doi:10.1016/j.bbrc.2006.03.002. PMID 16554024.  External links MeSH ABCB9+protein,+human This article incorporates text from the United States National Library of Medicine, which is in the public domain. v • d • e Membrane proteins, carrier proteins: membrane transport proteins ABC-transporter A1 · A2 · A3 · A4 · A7 · A8 · A12 · A13 B1 · B2-3 · B2 · B3 · B4 · B5 · B6 · B7 · B9 · B11 C1 · C2 · C3 · C4 · C5 · C6 · C8-9 (C8, C9) · C10 · C11 · C13 D1 · D2 · D3 · D4 · E1 · F1 · F2 G1 · G2 · G4 · Sterolin (G5 · G8) Solute carrier 1-10 1A1-7 · 1A1 · 1A2 · 1A3 · 1A4 · 1A5 · 1A6 · 1A7 Glucose transporter: 2A1 (GLUT1) · 2A2 (GLUT2) · 2A3 (GLUT3) · 2A4 (GLUT4) · 2A5 (GLUT5) · 2A6 (GLUT6) · 2A7 (GLUT7) · 2A8 (GLUT8) · 2A9 · 2A10 · 2A12 3A1 · 3A2 · 4A1 · 4A2 · 4A3 · 4A4 · 4A5 · 4A7 · 4A8 · 4A11 · 5A1-2 · 5A1 · 5A3 · 5A4 · 5A5 · 5A8 · 6A1 · 6A2 · 6A3 · 6A4 · 6A5 · 6A8 · 6A9 · 6A18 · 6A19 · 6A20 · 7A1 · 7A2 · 7A3 · 7A4 · 7A5 · 7A6 · 7A7 · 7A8 · 7A9 · 7A10 · 7A11 · 8A1-3 · 9A1 · 9A2 · 9A3 · 9A3R1 · 9A3R2 · 9A5 · 9A6 · 9A8 · 9A10 · 9A11 · 10A1 · 10A2 · 10A3 · 10A7 11-20 11A1 · 11A2 · 11A3 · 12A1-2 · 12A3 · 12A4 · 12A5 · 12A6 · 12A7 · 14A1 · 13A3 · 14A2 · 15A1 · 15A2 · 16A1 · 16A2 · 16A3 · 16A4 · 17A1 · 17A5 · 17A6-8 · 17A7 · 18A1 · 18A2 · 18A3 · 19A1 · 19A2 · 19A3 · 20A1 · 20A2 21-30 22A1 · 22A2 · 22A3 · 22A4 · 22A5 · 22A6 · 22A7 · 22A9 · 22A10 · 22A11 · 22A12 · 22A18 · 22A25 · 23A1 · 23A2 · 24A1-2 · 24A5 · 25A1 · 25A3 · 25A4-6 (25A4, 25A6), 25A8 · 25A10 · 25A11 · 25A12 · 25A13 · 25A14 · 25A15 · 25A17 · 25A19 · 25A20 · 25A27 · 25A31 · 25A37 · 25A38 · 25A39 · 26A2 · 26A3 · 26A4 · 26A5 · 26A6 · 26A7 · 26A8 · 27A1 · 27A2 · 27A3 · 27A4 · 28A1 · 28A2 · 29A1 · 29A2 · 29A4 · 30A1 · 30A4 · 30A7 · 30A8 31-40 31A1 · 31A2 · 32A1 · 34A1 · 34A2 · 34A3 · 35A1 · 35A2 · 35B2 · 35B4 · 35C1 · 36A1 · 36A2 · 37A4 · 38A2 · 38A3 · 39A1 · 39A2 · 39A3 · 39A4 · 39A6 · 39A7 · 39A10 41-47 40A1 · 42A1 · 42A2 · 42A3 · 43A1 · 44A1 · 44A2 · 44A4 · 45A2 · 45A3 · 46A1 · 47A1 · 47A2 O O1A2 · O1B1 · O1B3 · O2B1 · O431 · O4A1 Other Amino acid (CD98) · Fatty acid (CD36) · Ion channels · Ion pumps · Mitochondrial membrane transport protein · Neurotransmitter transport proteins · Nuclear (Importin · Karyopherin) see also membrane transport protein disorders This membrane protein-related article is a stub. 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