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(February 2009) edit Hepatitis A virus cellular receptor 1 Identifiers Symbols HAVCR1; TIM1; HAVCR; HAVCR-1; KIM-1; KIM1; TIM-1; TIMD1 External IDs OMIM: 606518 MGI: 2159680 HomoloGene: 77133 GeneCards: HAVCR1 Gene Gene Ontology Molecular function • receptor activity Cellular component • membrane • integral to membrane Sources: Amigo / EGO RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 26762 171283 Ensembl ENSG00000113249 ENSMUSG00000040405 UniProt Q96D42 Q5QNS5 RefSeq (mRNA) NM_012206 NM_134248 RefSeq (protein) NP_036338 NP_599009 Location (UCSC) Chr 5: 156.39 - 156.42 Mb Chr 11: 46.58 - 46.62 Mb PubMed search [1] [2] Hepatitis A virus cellular receptor 1 is a protein that in humans is encoded by the HAVCR1 gene.[1][2][3] References ^ Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG (Aug 1998). "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor". J Virol 72 (8): 6621–8. PMID 9658108.  ^ McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH (Nov 2001). "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family". Nat Immunol 2 (12): 1109–16. doi:10.1038/ni739. PMID 11725301.  ^ "Entrez Gene: HAVCR1 hepatitis A virus cellular receptor 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26762.  Further reading Kumanogoh A, Kikutani H (2004). "Immune semaphorins: a new area of semaphorin research.". J. Cell. Sci. 116 (Pt 17): 3463–70. doi:10.1242/jcs.00674. PMID 12893810.  McIntire JJ, Umetsu DT, DeKruyff RH (2004). "TIM-1, a novel allergy and asthma susceptibility gene.". Springer Semin. Immunopathol. 25 (3-4): 335–48. doi:10.1007/s00281-003-0141-3. PMID 15007635.  Thompson P, Lu J, Kaplan GG (1998). "The Cys-rich region of hepatitis A virus cellular receptor 1 is required for binding of hepatitis A virus and protective monoclonal antibody 190/4.". J. Virol. 72 (5): 3751–61. PMID 9557657.  Bailly V, Zhang Z, Meier W, et al. (2002). "Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration.". J. Biol. Chem. 277 (42): 39739–48. doi:10.1074/jbc.M200562200. PMID 12138159.  Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.  Noguchi E, Nakayama J, Kamioka M, et al. (2003). "Insertion/deletion coding polymorphisms in hHAVcr-1 are not associated with atopic asthma in the Japanese population.". Genes Immun. 4 (2): 170–3. doi:10.1038/sj.gene.6363935. PMID 12618867.  McIntire JJ, Umetsu SE, Macaubas C, et al. (2003). "Immunology: hepatitis A virus link to atopic disease.". Nature 425 (6958): 576. doi:10.1038/425576a. PMID 14534576.  Chae SC, Song JH, Heo JC, et al. (2004). "Molecular variations in the promoter and coding regions of human Tim-1 gene and their association in Koreans with asthma.". Hum. Immunol. 64 (12): 1177–82. doi:10.1016/j.humimm.2003.09.011. PMID 14630400.  Chae SC, Song JH, Lee YC, et al. (2004). "The association of the exon 4 variations of Tim-1 gene with allergic diseases in a Korean population.". Biochem. Biophys. Res. Commun. 312 (2): 346–50. doi:10.1016/j.bbrc.2003.10.125. PMID 14637143.  Vilà MR, Kaplan GG, Feigelstock D, et al. (2004). "Hepatitis A virus receptor blocks cell differentiation and is overexpressed in clear cell renal cell carcinoma.". Kidney Int. 65 (5): 1761–73. doi:10.1111/j.1523-1755.2004.00601.x. PMID 15086915.  Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.  Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.  Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.  Mesri M, Smithson G, Ghatpande A, et al. (2006). "Inhibition of in vitro and in vivo T cell responses by recombinant human Tim-1 extracellular domain proteins.". Int. Immunol. 18 (3): 473–84. doi:10.1093/intimm/dxh388. PMID 16481347.  Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.  Kotsis F, Nitschke R, Boehlke C, et al. (2007). "Ciliary calcium signaling is modulated by kidney injury molecule-1 (Kim1).". Pflugers Arch. 453 (6): 819–29. doi:10.1007/s00424-006-0168-0. PMID 17205356.  This article on a gene on chromosome 5 is a stub. You can help Wikipedia by expanding it. v • d • e